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Pep Source Research Lab

Mazdutide

Mazdutide

$139.00
$139.00
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Mazdutide (IBI362 / LY3305677)
Dual GLP-1 and Glucagon Receptor Agonist
For Laboratory Research Reference Only – Not for Human Use

Overview (Simple Terms):
Mazdutide is a synthetic peptide designed to engage both GLP‑1 and glucagon receptors, combining appetite suppression with increased metabolic activity. It’s under development for obesity and type 2 diabetes management, and has become the world’s first approved dual GLP‑1/glucagon receptor agonist in China (as of June 2025) New England Journal of Medicine+10PR Newswire+10Fierce Pharma+10.

Research Highlights:

  • In clinical trials, weekly dosing of Mazdutide led to significant and sustained weight loss, often exceeding 10% over several months PR NewswireNatureNew England Journal of Medicine.

  • Improved HbA₁c levels (–1.4% to –1.7%) and body weight reductions up to –7.1% in individuals with type 2 diabetes PMC.

  • Demonstrated major reduction in liver fat content in patients with elevated baseline levels—up to –80% for the 6 mg dose PMC+3PR Newswire+3Fierce Pharma+3.

  • Generally well-tolerated; common side effects include nausea, diarrhea, decreased appetite, and upper respiratory infections Drugs.comPMC.

Specifications:

  • Weekly injectable dosing (under skin).

  • Dosage ranges from 3 mg to 6 mg in most studies; higher doses (9 mg) are under exploration.

  • Approval in China (NMPA) for overweight/obese adults with comorbidities (as of June 2025) Drugs.comFierce Pharma+2PMC+2PR Newswire+1.

Research Notes:

  • As a dual agonist, Mazdutide may help both reduce calorie intake (via GLP‑1 action) and increase energy expenditure (via glucagon receptor activity).

  • Explored for treating obesity, type 2 diabetes, and metabolic liver disease (due to liver fat reduction) Fierce PharmaNature.

FDA Disclaimer:
This description is intended for laboratory research purposes only. Mazdutide is not a drug, dietary supplement, or cosmetic, and is not intended for human or animal consumption. It has not been evaluated by the U.S. FDA for safety or effectiveness outside approved contexts.

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